Deciphering the mechanisms underlying increased risk of brain metastases in young women with triple negative breast cancer. These include ovarian estrogen effects on reactive astrocytes that results in paracrine activation of EGFR and TRKB signaling in brain metastatic cells.
Elucidating the effects of aromatase function and brain-synthesized estrogen in neuroinflammation in brain metastases from breast and other cancers.
Validating IL13RA2 as a targetable candidate for breast cancer brain metastasis.
Developing novel patient-derived xenograft models from breast cancer brain metastases, as well as novel imaging methods to map brain metastases to specific brain niches.