Associate Professor of Orthopedics
We focus on the genetic regulation of bone mass and the genetic causes of bone disease from the point of view of bone formation and strength. We use both forward and reverse genetics studies to interrogate the genetic causes of phenotypes critical to understanding bone quality that cannot be readily studied in human populations. These phenotypes of interest include bone composition, bone formation and mineralization by the osteoblast. In addition, we participate in many human cohort studies aimed at understanding the etiology of musculoskeletal disease wherein we determine the biological function of genes found to be associated with musculoskeletal traits.
The goal of this project is to genetically dissect one of the most of Osteoblast Activity important processes affecting bone, osteoblast-mediated bone formation. We hypothesize that by focusing on a cellular phenotype and employing systems genetics methodologies, we will have increased success in discovering genes that specifically modulate bone formation, as compared to traditional mapping studies of higher-level phenotypes.