Omid Masihzadeh, Ph.D.

Assistant Research Professor

Omid MasihzadehDr. Masihzadeh’s research has been focused towards two main subjects, laser assisted multiphoton microscopy, and development of laser assisted surgical tools. Functional and structural multiphoton imaging, including second harmonic generation (SHG), third harmonic generation (THG), two-photon autofluorescent (2PAF), Raman spectroscopy, and coherent anti-Stokes Raman spectroscopy, has found increasing interest in the laboratory-based research. Properties like subcellular resolution, along with the ability to obtain structural imaging make these modalities unique compared to linear imaging modalities. Dr. Masihzadeh’s goal is on optimizing these tools for ocular specific research.

Femtosecond lasers, the centerpiece in multiphoton microscopy, have been recently introduced as an important tool to assist in performing ocular surgeries. The currently available cataract surgery femtosecond lasers help with creating corneal incisions, incising the anterior capsule of the lens and partially fragmenting the lens. It has become clear however that there are performance limitations inherent to the hardware used in these devices. Further development of femtosecond ocular surgery hardware is another goal in Dr. Masihzadeh’s research.

Selected Publications

See a complete list of Omid Masihzadeh's publications →

O. Masihzadeh, T. C. Lei, S. R. Domingue, M. Y. Malik, R. A. Bartels, D. A. Ammar, “Third harmonic generation (THG) microscopy of a mouse retina”, Mol. Vis, (21). 2015
T. C. Lei, O. Masih​zadeh, M. Y. Kahook, D. A. Ammar, “Imaging the effect of Prostaglandins on Cultured Trebecular Meshwork Cells by Coherent Anti-Stokes Raman Scattering (CARS)” IOVS. 54(9) (2013)
D. A. Ammar, T. C. Lei, Ma. Y. Kahook, O. Masihzadeh, “Imaging the intact mouse cornea using coherent anti- Stokes Raman scattering (CARS)” IOVS. 54(8) (2013)
O. Masihzadeh, D. A. Ammar, M. Y. Kahook, T.C. Lei, “Coherent anti-Stokes Raman scattering (CARS) microscopy: a novel technique for imaging the retina”, IOVS 54(5) (2013)
O. Masihzadeh, D. A Ammar, M. Y. Kahook, E. A Gibson, T. C Lei, “ Multiphoton Gonioscopy to image the trabecular meshwork of porcine eyes”, Pro. SPIE (2013)
E. Block, M. Greco, D. Vitek, O. Masihzadeh, D. A. Ammar, M. Y. Kahook, N. Mandava, C. Durfee, J. Squier, “Simultaneous spatial and temporal focusing for tissue ablation”. J. Biomed. Opt. 4(6), 2013
O. Masihzadeh, D. Ammar, M. Y. Kahook, E. Gibson, T.C. Lei, “Direct trabecular meshwork imaging in porcine eyes through multiphoton gonioscopy” J. Biomed. Opt. 18(3) (2013)
O. Masihzadeh, T.C. Lei, D. Ammar, E. Gibson, M.Y. Kahook, “A multiphoton microscope platform for imaging the mouse eye”, Mol. Vis. 18 (2012)
T.C. Lei, D. Ammar, O.Masihzadeh, E. Gibson, M.Y. Kahook, “Label-free imaging of trabecular meshwork cells using Coherent Anti-Stokes Raman Scattering (CARS) microscopy”, Mol. Vis. (2011)
O.Masihzadeh, D. Ammar, T.C. Lei, E.Gibson, M.Y. Kahook, “Real-time measurement of nicotinamide adenine dinucleotide in live human trabecular meshwork cells: Effect of acute oxidative stress”, Exp Eye Res (2011)
P. Schlup, O. Masihzadeh, R. A. Bartels, “High-speed, label-free second harmonic generation holographic microscopy of biological specimens” Proc. SPIE Vol. 7903 (2011)
D. A. Ammar, T. C. Lei, O. Masihzadeh, E. A. Gibson, and M. Y. Kahook, “Trans-Scleral Imaging of Human Trabecular Meshwork by Two-Photon Microscopy”, Journal of Ophthalmology (2011)
E. A. Gibson, O. Masihzadeh, T. C. Lei, D. A. Ammar and M. Y. Kahook, “Multi-photon microscopy for ophthalmic imaging”, Journal of Ophthalmology (2011)
L. Llanzano, T. Lei, K. Okamura, H. Giral, Y. Caldas, O. Masihzadeh, E. Gratton, M. Levi, J. Blaine, “Differential Modulation of the Molecular Dynamics of the Type IIa And IIc Sodium Phosphate Cotransporters by Parathyroid Hormone”, Am. J. Physiol Cell 301(4) (2011).   
O. Masihzadeh, P. Schlup and R.A Bartels, “Label-free second harmonic generation holographic microscopy of biological specimens.”, Opt. Express 18 , 9840-9851 (2010).
D.Kupka, O.Masihzadeh, P.Schlup, R. A. Bartels,  “Polarization control and tomography for nonlinear microscopy”, SPIE, (2010)
D. Kupka, J. Wilson, O. Masihzadeh, R.A Bartels, “Distinguishing bulk and interface modulation of optical third harmonic generation due to coherent optical phonon excitation Corresponding”, Chem. Phys. Lett. 490 , 97-101 (2010).
L. Xu, P. Schlup, O. Masihzadeh, R.A. Bartels, R. Tribino, “ Analysis of the measurement of polarization- shaped ultrashort laser pulses by tomographic ultrafast retrieval of transverse light E-fields (TURTLE)”, J. Opt. Soc. Am. B , 26, 2363-2369 (2009).
O. Masihzadeh, P. Schlup and R.A Bartels “Enhanced spatial resolution in third-harmonic microscopy through polarization switching”, Opt. Lett. 34 , 1240-1242 (2009).
O. Masihzadeh, P. Schlup and R.A Bartels “Control and measurement of spatially inhomogeneous polarization distributions in third-harmonic generation microscopy”, Opt. Lett. 34 , 1090-1092 (2009).
P. Schlup, O. Masihzadeh, and R.A Bartels “Tomographic retrieval of the polarization  state of an ultrafast laser pulse.”, Opt. Lett. 33 , 267-269 (2008).
P. Schlup, O. Masihzadeh, L.Xu, R. Trebino and R.A Bartels “Polarization,Phase and Amplitude control and Characterization of Ultrafast Laser Pulses”, Ultrafast Phenomena XVI, Stressa, Italy, (2008)
O. Masihzadeh, P. Schlup and R.A Bartels “Complete polarization state control of ultrafast laser pulses with a single linear spatial light modulator.”, Opt. Express 15 , 18025-18032 (2007).
O. Masihzadeh, M. Baertschy, and R.A Bartels, “Rotational wave packet dynamics correlated to ultrafast non-time-stationary linear and nonlinear optical susceptibilities”, Proceeding in Ultrafast Phenomena XV, Pacific Grove, CA, (2007)
O. Masihzadeh, M. Baertschy and R.A Bartels “Optimal single pulse excitation of rotational impulsive molecular phase  modulation.”, Opt. Express 14 , 2520-2532 (2006).
O. Masihzadeh, M. Baertschy, K. Hartinger, and R. A. Bartels, "Transient optical susceptibility induced by nonperturbative rotational wave packets," Proceedings of Ultrafast Optics V. (2007)
M.E. Huber, A. P. Neil, R.G. Benson, D, A. Burns, A.M. Cory, C.S. Flynn, Y. Kitaygorodskaya, O. Massihzadeh, J. M. Martinis, and G.C Hilton, “ DC SQUID Series Array Amplifiers with 120 MHz Bandwidth”, IEEE Trans. Appl. Superconductivity, vol 11, pp. 1251-1256 (2001)