Kvaratskhelia Lab Discovers Human Protein that Regulates the HIV-1 Life CycleDepartment of Medicine Mar 3, 2021
Virologist and professor of medicine Mamuka Kvaratskhelia, PhD, and colleagues in the Division of Infectious Diseases have published in Nature Microbiology their discovery that a human cellular protein – Sec24c – critically regulates HIV-1. Sec24c, binds to the outer shell (capsid core) of an incoming virus and is necessary for proper infectivity. First authors are Stephanie Rebensburg, PhD and Guochao Wei, PhD.
Other collaborators included the Poeschla laboratory. Understanding the dependency of HIV-1 on this protein may have implications for therapeutic intervention. Notably the discovery follows on their recent report in Science on an ultra-potent new antiviral drug that also binds to a similar region on the incoming capsid. Read more.