We use state-of-the-art, transformational research platforms to decipher the unique biology and disease spectrum caused by trisomy of chromosome 21. 

Our ultimate goal is to enable precision medicine approaches to improve health outcomes in Down syndrome, including the development of new diagnostic and therapeutic tools.​​​

The Linda Crnic Institute logo is a dark blue circle encompassing three double helixes, representing the triplication of chromosome 21

A ribbon diagram depicting the chromosome 21 encoded gene, MORC3

​Dr. Kutateladze describes mechanism of activation and inhibition of chromosome 21 gene, MORC3


The face of a baby with Down syndrome laying in a white blanket

Dr. Hickey publishes clinical characterization of infantile spas​ms in children with Down syndrome


A man who has Down syndrome and alopecia aerate stands in front of bleachers and appears to be wearing workout gear, including a water bottle and headphones

​Crnic scientists publish first reported cases of immunotherapy to treat alopecia areata in Down syndrome


We are the largest geographical cluster of Down syndrome researchers in the world​

Comprised of over 50 Principal Investigators and countless more contributing scientists from across the University of Colorado campuses, our researchers bring expertise from a variety of fields.

Together, we are working to decipher the complex mechanisms and multi-faceted health impacts of trisomy 21.

The Linda Crnic Institute logo is a dark blue circle encompassing three double helixes, representing the triplication of chromosome 21

Scientists in lab coats talking in the lab

We need partners like you to grow and accelerate our work

Ours is a mission that was never meant to be accomplished alone. We are grateful for our scientists, business partners, generous donors, and brave research volunteers, and we cannot continue moving forward without your sustained support.