We use state-of-the-art, transformational research platforms to decipher the unique biology and disease spectrum caused by trisomy of chromosome 21. 

Our ultimate goal is to enable precision medicine approaches to improve health outcomes in Down syndrome, including the development of new diagnostic and therapeutic tools.​​​

The Linda Crnic Institute logo is a dark blue circle encompassing three double helixes, representing the triplication of chromosome 21

Artistic rendering of metabolites

Crnic Institute scientists publish metabolomics study revealing kynurenine pathway activation in trisomy 21

Huntington Potter speaking into a microphone for a podcast

Dr. Potter is featured on the CU Anschutz 360 podcast for a candid discussion about the state of Alzheimer’s research

An audience of people are sitting in stadium seating. On the stage, a presenter stands behind a podium and shows information on a large projector

Our annual Down Syndrome Research Symposium is on September 25th at the Anschutz Campus

A female clinician listens to the chest of a small girl with Down syndrome with a stethoscope

Sie Center clinicians evaluate the association of dysphagia with age and other respiratory comorbidities


We are the largest geographical cluster of Down syndrome researchers in the world​

Comprised of over 50 Principal Investigators and countless more contributing scientists from across the University of Colorado campuses, our researchers bring expertise from a variety of fields.

Together, we are working to decipher the complex mechanisms and multi-faceted health impacts of trisomy 21.

The Linda Crnic Institute logo is a dark blue circle encompassing three double helixes, representing the triplication of chromosome 21

Scientists in lab coats talking in the lab

We need partners like you to grow and accelerate our work

Ours is a mission that was never meant to be accomplished alone. We are grateful for our scientists, business partners, generous donors, and brave research volunteers, and we cannot continue moving forward without your sustained support.