We use state-of-the-art, transformational research platforms to decipher the unique biology and disease spectrum caused by trisomy of chromosome 21. 

Our ultimate goal is to enable precision medicine approaches to improve health outcomes in Down syndrome, including the development of new diagnostic and therapeutic tools.​​​

The Linda Crnic Institute logo is a dark blue circle encompassing three double helixes, representing the triplication of chromosome 21

COVID pathology in DS graphical abstract

Should people with Down syndrome be considered high-risk during COVID-19? Dr. Espinosa reviews the evidence.

Megan Bomgaars speaks at World Down Syndrome Day

CU Anschutz at the forefront of breakthroughs in Down syndrome research on World Down Syndrome Day

Dr. Espinosa speaks with other scientists in the lab

CU Anschutz is the new epicenter of Down syndrome research in the nation

Dr. Barry Martin listens with a stethoscope to a young man with Down syndrome

Read Global's statement about what COVID-19 means for people with Down syndrome

by GDSF  |  05.19.2020

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We are the largest geographical cluster of Down syndrome researchers in the world​

Comprised of over 50 Principal Investigators and countless more contributing scientists from across the University of Colorado campuses, our researchers bring expertise from a variety of fields.

Together, we are working to decipher the complex mechanisms and multi-faceted health impacts of trisomy 21.

The Linda Crnic Institute logo is a dark blue circle encompassing three double helixes, representing the triplication of chromosome 21

Scientists in lab coats talking in the lab

We need partners like you to grow and accelerate our work

Ours is a mission that was never meant to be accomplished alone. We are grateful for our scientists, business partners, generous donors, and brave research volunteers, and we cannot continue moving forward without your sustained support.