We use state-of-the-art, transformational research platforms to decipher the unique biology and disease spectrum caused by trisomy of chromosome 21. 

Our ultimate goal is to enable precision medicine approaches to improve health outcomes in Down syndrome, including the development of new diagnostic and therapeutic tools.​​​

The Linda Crnic Institute logo is a dark blue circle encompassing three double helixes, representing the triplication of chromosome 21

Artistic rendering of an immune cell

Crnic Institute and Argentina scientists collaborate to show T cell lineages are dysregulated in Down syndrome

Actress Laura Linney with a runway fashion participant

Be Beautiful Be Yourself Fashion Show raises $2.5 million for Down syndrome research

Artistic rendering of metabolites

Crnic Institute scientists publish metabolomics study revealing kynurenine pathway activation in trisomy 21

Huntington Potter speaking into a microphone for a podcast

Dr. Potter is featured on the CU Anschutz 360 podcast for a candid discussion about the state of Alzheimer’s research


We are the largest geographical cluster of Down syndrome researchers in the world​

Comprised of over 50 Principal Investigators and countless more contributing scientists from across the University of Colorado campuses, our researchers bring expertise from a variety of fields.

Together, we are working to decipher the complex mechanisms and multi-faceted health impacts of trisomy 21.

The Linda Crnic Institute logo is a dark blue circle encompassing three double helixes, representing the triplication of chromosome 21

Scientists in lab coats talking in the lab

We need partners like you to grow and accelerate our work

Ours is a mission that was never meant to be accomplished alone. We are grateful for our scientists, business partners, generous donors, and brave research volunteers, and we cannot continue moving forward without your sustained support.