We use state-of-the-art, transformational research platforms to decipher the unique biology and disease spectrum caused by trisomy of chromosome 21. 

Our ultimate goal is to enable precision medicine approaches to improve health outcomes in Down syndrome, including the development of new diagnostic and therapeutic tools.​​​

The Linda Crnic Institute logo is a dark blue circle encompassing three double helixes, representing the triplication of chromosome 21

CU Our COVID Fighters

Crnic Institute and CU scientists secure $1 million to explore COVID-19 in Down syndrome

Crnic and Global logo

NIH and Fast Grants award $1M to the Crnic Institute to study COVID-19 in people with Down syndrome

Pentacam scans from individuals with DS

Sie Center and University researchers investigate corneal morphology in young individuals with Down syndrome

VOA hyper immune system video shot

Hyper Immune System May Be Key to Down Syndrome Symptoms



We are the largest geographical cluster of Down syndrome researchers in the world​

Comprised of over 50 Principal Investigators and countless more contributing scientists from across the University of Colorado campuses, our researchers bring expertise from a variety of fields.

Together, we are working to decipher the complex mechanisms and multi-faceted health impacts of trisomy 21.

The Linda Crnic Institute logo is a dark blue circle encompassing three double helixes, representing the triplication of chromosome 21

Scientists in lab coats talking in the lab

We need partners like you to grow and accelerate our work

Ours is a mission that was never meant to be accomplished alone. We are grateful for our scientists, business partners, generous donors, and brave research volunteers, and we cannot continue moving forward without your sustained support.