Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells >>
Selected as one of the "Best of Cancer Cell 2018"
October 8, 2018, by Cancer Cell Journal
It is well established that cancer cells consume more glucose than normal cells, a component of malignant cell bioenergetics that has been documented in numerous studies (Hay, 2016).To date though, studies have mainly focused on cell-intrinsic
mechanisms by which glucose is preferentially utilized, such s activation of glucose transporters and glycolysis. In the present study, we sought to approach glucose metabolism from a holistic perspective and to consider how cancer
cells manage their need for glucose in the context of an entire mammalian organism. We note that, relative to the total tissue mass of an organism, the volume of the tumor is generally low. Therefore, we hypothesized that activation
of intrinsic pathways alone may not be sufficient to provide adequate glucose to drive robust cancer cell growth...
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