Cardiac Arrest & Resuscitation Research

Welcome to the Cardiac Arrest and Resuscitation Research page at the University of Colorado, Anschutz Medical Campus in the Department of Emergency Medicine. Our research team is focused on investigating ways to improve overall survival and neurologic recovery after cardiac arrest. We are currently engaged in local and national studies to address multiple topics in cardiac arrest outcomes research that will help to save lives. 

The specific areas of interest that are currently being addressed by our research team include, but are not limited to:  

  • Sex differences in cardiac arrest outcomes
  • Neuro-prognostication for comatose survivors of cardiac arrest
  • Decision-making in cardiac arrest care
  • Optimizing the delivery of post-cardiac arrest care including Targeted Temperature Management (TTM) 

To accomplish our research goals, our team consists of physician scientists, clinical experts in post-cardiac arrest care and intensive care medicine, trainees at the pre- and post-doctoral level, and highly-skilled professional research assistants with advanced methodological experience.  

Our interests span from pre-hospital and community engagement in cardiopulmonary resuscitation to emergency department management and critical care treatment of the post-cardiac arrest patient. CU is a member of the Strategies to Innovate Emergency Care Clinical Trials Network (SIREN) and our group is also actively engaged in other multi-center collaborations focused upon improving cardiac arrest care. We are actively engaged in continuing medical education training courses and community engagement to advance CPR training.

Thank you for visiting our research team information page.   
Sarah Perman, MD MSCE   

Our Team

Picture of Sarah Perman

Sarah M. Perman, MD MSCE
Associate Professor

Picture of Shelby Shelton

Shelby Shelton, MPH
Professional Research Assistant

Picture of Bonnie Siry

Bonnie Siry, MSSc
Professional Research Assistant

Picture of Alexander Prescuitti

Alex Presciutti, MS
Graduate Student (Clinical Psychology), CCTSI/TL1 Fellow 

1R03 HL148366-01
Limited Competition:  Small Grant Program
NIH National, Heart Lung, Blood Institute
Exploring Institutional Variability in Neuro-prognostication for Survivors of Cardiac Arrest
Principal Investigator:  Sarah M. Perman, MD MSCE

1K23 HL138164-03
Mentored Patient-Oriented Research Career Development Award
NIH National, Heart, Lung, Blood Institute
Improving Care After Cardiac Arrest by Informing Surrogate Decision Makers
Principal Investigator: Sarah M. Perman, MD MSCE

Center for Women’s Health Research
5/2018 – 5/2020
University of Colorado, Anschutz Medical Campus
Junior Faculty Interdisciplinary Research Award
Assessing public perceptions and identifying targets for intervention to reduce disparities in
the provision of bystander CPR for women after cardiac arrest
Principal Investigator:  Sarah M. Perman, MD MSCE

Doris Duke Fund
University of Colorado, School of Medicine

5K12 HD057022-09
8/2015 – 8/2017
Building Interdisciplinary Research Careers in Women’s Health Program
NIH Eunice Kennedy Shriver National Institute of Child Health and Human Development
University of Colorado, School of Medicine

Center for Women’s Health Research
11/2014 – 10/2016
University of Colorado, Anschutz Medical Campus
Junior Faculty Research Development Award
Gender Differences in the Decision to Withdraw Life Sustaining Therapy After Cardiac Arrest
Principal Investigator:  Sarah M. Perman, MD MSCE

University of Colorado Hospital
7/2013 – 7/2015
Clinical Effectiveness and Patient Safety Small Grants Program
Efficacy and Utility of Continuous Electroencephalography in Patients Surviving Cardiac Arrest
Co-Principal Investigators:  Sarah M. Perman MD, MSCE; Ellen Burnham, MD, MSc; Archana Shrestha, MD
Grossestreuer AG, Abella BS, Leary M, Perman SM, Fuchs BD, Kolansky DM, Beylin ME, Gaieski DF. Time to arousal and neurologic outcome in therapeutic-hypothermia treated post-cardiac arrest patients.  Resuscitation. 2013;84(12):1741-6

Perman SM, Goyal M, Neumar RW, Topjian A, Gaieski DF.  Clinical applications of targeted temperature management. CHEST.2014;145(2):386-93

Cristia C, Ho M, Levy S, Anderson LW, Perman SM, Giberson T, Salciccioli J, Saindon B, Cocchi MN, Donnino MW. The association between a quantitative computed tomography (CT) measurement of cerebral edema and outcomes in post-cardiac arrest – a validation study. Resuscitation 2014 Oct;85(10):1348-53.

Johnson NJ, Acker M, Hsu CH, Desai N, Vallabhajosyula P, Lazar S, Horak J, Wald J, McCarthy F, Rame E, Gray K, Perman SM, Becker L, Grossestreuer A, Smith T, Gaieski DF. Extracorporeal life support as rescue strategy in out-of-hospital and emergency department cardiac arrest. Resuscitation, 2014 Nov;85(11):1527-32

Mazer M, Perman SM, Grossestreuer AV, Neumar RW, Gaieski DF. Magnesium depletion in patients treated with therapeutic hypothermia after cardiac arrest. Therapeutic Hypothermia and Temperature Management. 2014 Dec;4(4):188-92

Ranola PA, Merchant RM, Perman SM, Khan A, Gaieski DF, Caplan AL, Kirkpatrick JN. How long is long enough, and have we done everything we should?- Ethics of calling codes. Journal of Medical Ethics. 2015 Aug;41(8):663-6.

Perman SM, Ellenberg JH, Grossestreuer AV, Gaieski DF, Leary M, Abella BS, Carr BG. Prolonged time to target temperature is associated with poor neurologic outcome in post-arrest patients treated with targeted temperature management. Resuscitation. 2015 Mar;88:114-9.

Wigginton JG, Perman SM, Barr BC, McGregor AJ, Miller A, Napoli A, Safdar B, Weaver KR, Deutsch S, Kayea T, Becker LB. Sex and Gender Specific Research Priorities in Cardiovascular Resuscitation: Proceedings from the 2014 AEM Consensus Conference Resuscitation Research Workgroup. Acad Emerg Med. 2014 Dec;21(12):1343-9.

Ramjee V, Grossestreuer AV, Yao Y, Perman SM, Leary M, Kirkpatrick J, Forfia P, Kolansky D, Abella BS, Gaieski DF. Right ventricular dysfunction after resuscitation predicts poor outcomes in cardiac arrest patients independent of left ventricular function. Resuscitation. 2015 Aug;28;96:186-91.

Fendler T, Spertus JA, Kennedy KF, Chen LM, Perman SM, Chan PS; American Heart Associations Get With the Guidelines-Resuscitation Investigators. Alignment of Do-Not-Resuscitate Status With Patients’ Likelihood of Favorable Neurological Survival After In-Hospital Cardiac Arrest. JAMA. 2015 Sep 22-29;314(12):1264-71

Perman SM, Grossestreuer AV, Wiebe D, Carr BG, Abella BS, Gaieski DF. The utility of therapeutic hypothermia for comatose survivors of cardiac arrest with an initial non-shockable rhythm. Circulation. 2015 Dec 1;132(22):2146-51

Johnson NJ, Dodampahala K, Rosselot B, Perman SM, Mikkelsen ME, Goyal M, Gaieski DF, Grosesstreuer AV. The association between arterial oxygen tension and neurological outcome after cardiac arrest. Therapeutic Hypothermia and Temperature Management. 2016 July 6

Agarwal AK, Gaieski DF, Perman SM, Leary M, Delfin G, Abella BS, Carr BG. Telemedicine REsuscitation and Arrest Trial (TREAT): A feasibility study of real-time provider-to-provider telemedicine for the care of critically ill patients. Heliyon. 2016 April; 2(4)

Sarkari N, Perman SM, Ginde AA. Impact of early Do-Not-Attempt-Resuscitation Orders on Procedures and Outcomes of Severe Sepsis. J Crit Care. 2016 Jul 9;36:134-139

Johnson NJ, Rosselot B, Perman SM, Dodampahala K, Goyal M, Gaieski DF, Grossestreuer AV. The association between hemoglobin concentration and neurologic outcome after cardiac arrest. J Crit Care. 2016 Jul 17;36:218-222

Grossestreuer AV, Abella BS, Sheak KR, Cinousis MJ, Perman SM, Leary M, Wiebe DJ, Gaieski DF. Inter-rater reliability of post-arrest cerebral performance category (CPC) scores. Resuscitation. 2016 Sep 17;109:21-24

Perman SM, Stanton E, Soar J, Berg R, Donnino MW, Mikkelson ME, Edelson D, Churpek MM, Yang L, Merchant RM. Location of In Hospital Cardiac Arrest in the US – Variability in event rate and outcomes. JAHA. 2016 Sep 29;5(10)

Grossestreuer AV, Gaieski DF, Abella BS, Wiebe DJ, Ikeda DJ, Haukoos JS, Perman SM. Factors Associated with Post-Arrest Withdrawal of Life-Sustaining Therapy.  Resuscitation. 2017 Jan;110:114-119

Bradley SM, Liu W, Chan PS, Girotra S, Goldberger ZD, Valle JA, Perman SM, Nallamothu BK; American Heart Association’s Get With the Guidelines-Resuscitation Investigators. Duration of resuscitation efforts for in-hospital cardiac arrest by predicted outcomes: Insights from get with the guidelines-Resuscitation.  Resuscitation. 2017 Apr;113:128-134. PMID:28039064

McGregor AJ, Beauchamp GA, Wira CR 3rd, Perman SM, Safdar B. Sex as a Biological Variable in Emergency Medicine Research and Clinical Practice: A Brief Narrative Review. West J Emerg Med. 2017 Oct;18(6):1079-1090. PMID:29085541

Thompson LE, Chan PS, Tang F, Nallamothu BK, Girotra S, Perman SM, Bose S, Daugherty SL, Bradley SM; American Heart Association’s Get With the Guidelines-Resuscitation Investigators. Long-Term Survival Trends of Medicare Patients After In-Hospital Cardiac Arrest: Insights from Get With The Guidelines-Resuscitation. Resuscitation. 2018 Feb; 123: 58-64. PMID:29102470  

Shelton SK, Chukwulebe SC, Gaieski DF, Abella BS, Carr BG, Perman SM. Validation of an ICD Code for Accurately Identifying Emergency Department Patients Who Suffer an Out-Of-Hospital Cardiac Arrest.Resuscitation. 2018 Apr; 125: 8-11. PMID:29341874

Uber AJ, Perman SM, Cocchi MN, Patel PV, Ganley SE, Portmann JM, Donnino MW, Grossestreuer AV. Increased Heat Generation in Postcardiac Arrest Patients During Targeted Temperature Is Associated With Better Outcomes. Crit Care Med. 2018 Apr 3 (Epub Ahead of Print). PMID:29620555

Hsu CH, Haac BE, Drake M, Bernard AC, Aiolfi A, Inaba K, Hinson HE, Agarwal C, Galante J, Tibbits EM, Johnson NJ, Carlbom D, Mirhoseini MF, Patel MB, OʼBosky KR, Chan C, Udekwu PO, Farrell M, Wild JL, Young KA, Cullinane DC, Gojmerac DJ, Weissman A, Callaway C, Perman SM, Guerrero M, Aisiku IP, Seethala RR, Co IN, Madhok DY, Darger B, Kim DY, Spence L, Scalea TM, Stein DM. EAST Multicenter Trial on Targeted Temperature Management for Hanging-Induced Cardiac Arrest. J Trauma Acute Care Surg. 2018 Jul;85(1):37-47. PMID:29677083

Agarwal S, Spiekerkoetter E, Austin E, de Jesus Perez V, Dezfulian C, Maron B, Ryan JJ, Starks MA, Yu P, Bonnet S, Perman SM. On behalf of the Early Career Committee of the 3 CPR Council of the American Heart Association (AHA). Career Development of Young Physician Scientists in the Sciences Perspective and Advice from the Early Career Committee of the Cardiopulmonary, Critical Care and Resuscitation (3 CPR) Council of the American Heart Association (AHA). Circ Res. 2018 May 11;122(10):1330-1333. PMID:29748361

Holmberg MJ, Moskowitz A, Wiberg S, Grossestreuer AV, Yankama T, Witten L, Perman SM, Donnino MW, Andersen L, for the American Heart Association’s Get With The Guidelines-Resuscitation Investigators. Guideline Removal of Atropine and Survival after Adult In-Hospital Cardiac Arrest with a Non-Shockable Rhythm. Resuscitation. 2019 Feb 13;137:69-77. PMID:30771452

Perman SM, Shelton SK, Knoepke C, Rappaport K, Matlock DD, Adelgais K, Havranek EP, Daugherty SL. Public Perceptions on Why Women Receive Less Bystander CPR than Men in Out of Hospital Cardiac Arrest. Circulation. 2019 Feb 19;139(8):1060-1068. PMID:30779655

Jarman AF, Mumma BE, Perman SM, Kotini-Shah P, McGregor AJ. When the Female Heart Stops: Sex & Gender Differences in Cardiac Arrest Resuscitation. Clinical Therapeutics. 2019 Jun;41(6):1013-1019. PMID:31053294

Perman SM, Siry BJ, Ginde AA, Grosesstreuer AV, Abella BS, Daugherty SL, Havranek EP. Sex differences in “Do Not Attempt Resuscitation” orders after out-of-hospital cardiac arrest and the influence on continued procedures. Clinical Therapeutics. 2019 Jun;41(6):1029-1037. PMID:31047712

Geocadin RG, Callaway CW, Fink E, Golan E, Greer DM, Ko NU, Lang E, Licht DJ, Marino BS, McNair N, Peberdy MA, Perman SM, Sims DB, Soar J, Sandroni C. Standards for Studies of Neurologic Prognostication in Comatose Survivors of Cardiac Arrest:A Scientific Statement From the American Heart Association. Circulation. 2019 Aug 27;140(9):e517-e542. PMID:31291775

Perman SM, Beaty BL, Daugherty SL, Havranek EP, Haukoos JS, Juarez-Colunga E, Bradley SM, Fendler TJ, Chan PS. Do Sex Differences Exist for Do Not Attempt Resuscitation Orders and Survival in Patients Successfully Resuscitated from In-Hospital Cardiac Arrest? J Am Heart Assoc. 2020 Feb 18;9(4). PMID:32063126

Knippa S, Butler J, Johnson L, Perman SM. The Cold Truth about Post-Arrest Targeted Temperature Management:When Do We Target 33°C versus 36°C? Nursing Critical Care, In Press.

Teran F, Perman SM, Mitchell O, Sawyer KN, Blewer AL, Rittenberger JC, Rivera M, Horowitz JM, Tonna JE, Hsu CH, Kotini-Shah P, McGovern SK, Abella BS. Highlights from the 2019 American Heart Association’s Resuscitation Science Symposium. In Press

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