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B cells play a significant role in the pathogenesis of Type 1 Diabetes (T1D), with evidence suggesting they may have a greater impact in patients diagnosed at a young age. To explore this, Jessica Prendergast plans to utilize single-cell sequencing to analyze transcriptional profiles, antigen affinity, reactivity, and repertoire differences across B cell subsets in young-onset versus adult-onset T1D.
This work aims to enhance our current limited understanding of the role of B cells in the two endotypes of T1D and the role of B cell polyreactivity in driving disease. These findings could be translated to age-appropriate therapeutic treatments.
When: March 31, 2025, 12 pm to 1 pm
Where: Barbara Davis Center (M20), Level 2, Main Conference Room 2104
Speaker:
Jessica Prendergast
PhD Student, Immunology
University of Colorado
Biography