University of Colorado Anschutz Medical Campus, Department of Medicine
Dr. Lyons' laboratory focuses on mechanisms of lymphatic mediated metastasis of breast cancer. Specifically, utilizing mouse models to investigate developmentally regulated programs of inflammation and lymphangiogenesis that are utilized in the adult mammary gland and may be hijacked by breast tumor cells. The results of these translational studies have the potential to instruct therapy aimed at prevention of breast cancer metastasis.
Students will: a) perform cell culture, b) perform IHC analysis of normal and tumor associated mouse and human mammary tissues, c) analyze gene expression by RT-PCR and protein expression by western blot in cell lines and/or tissues, d) analyze data and prepare graphs and e) interpret and discuss results according to the literature.