University of Colorado Anschutz Medical Campus, Department of Pharmacology, Aurora
The overall goal of this project is to understand how mitochondrial dynamics contribute to cancer progression.
The student will utilize tissue culture and cell biology techniques to study the impact of mitochondria shape, number and subcellular distribution in tumor cell invasion and metastatic dissemination. Molecular approaches routinely used include gene knockdown, gene expression analyses by quantitative-PCR, and protein assays such as Western blots and immunoprecipitation. The student will be trained and provided with laboratory protocols, standard procedures and functional assays required by this project.