The Clinical Epidemiology program has a robust research program investigating predictors of complications of type 1 diabetes. The Coronary Artery Calcification in Type 1 Diabetes (CACTI) study examined risk factors and incidence of cardiovascular complications (Dr. Rewers, PI). CACTI has since added assessments for other complications, including diabetic nephropathy, retinopathy and neuropathy (Dr. Snell-Bergeon, PI). In addition, several ancillary studies related to the CACTI cohort are ongoing. Dr. Snell-Bergeon is examining cardiovascular risk protection during the premenopausal years, as well as novel proteomic, metabolomic and lipidomic markers of diabetic kidney disease, HDL function in cardiovascular disease risk among adults with type 1 diabetes, and how reproductive hormones affect vascular and bone health in women with type 1 diabetes.