Abigael Cheruiyot Harvey PhD
Asst Professor
- Anschutz Campus - Sch of Med - BDC Basic Research
Dr Cheruiyot Harvey’s lab aims to understand how stressors in the pancreatic beta-cell microenvironment interact with mRNA translation quality control mechanisms to trigger autoimmunity in Type 1 diabetes (T1D) and drive disease progression in Type 2 Diabetes (T2D). Ultimately their mission is to develop novel approaches to protect beta-cells from immune destruction, prevent progressive beta-cell failure in diabetes, and improve functionality of ex vivo beta-cells for cell replacement therapies. To uncover these mechanisms, they integrate biochemical and multi-omics tools—including reporter assays, ribosome profiling, sequencing, proteomics, and CRISPR/Cas9 screening—using complementary models ranging from cell lines and primary human/mouse/rat islets to stem cell–derived beta-cells and in vivo systems.