Zachary Macchi, MD - Instructor

Headshot of Dr. Zachary Macchi

Contact Info



Residency, Neurology, University of Colorado (University Hospital) Program

MD, University of Kansas School of Medicine

Professional Titles

Palliative Care and Aging Research Fellow


Zachary Macchi, MD, is an Aging and Palliative Care Research Fellow  in the Department of Neurology at the University of Colorado. He obtained his undergraduate and medical degrees at the University of Kansas and completed his residency in Neurology at the University of Colorado (CU) Anschutz. An area of ongoing interest to Dr. Macchi is palliative care for neurologic illness, or neuropalliative care. Throughout fellowship he continues to work on a number of projects related to neuropalliative care for patients with neurodegenerative conditions, like Alzheimer’s disease and Parkinson’s disease. His current work focuses on aggression as a behavioral disturbance in Parkinson’s disease and other forms of parkinsonism, identifying factors which contribute to such behaviors and their consequences for patients and caregivers while also researching ways to detect and manage aggression in the outpatient setting.

Recent Publications

Macchi ZA, Katz M, Galifianakis N, Sillau S, Miyasaki J, Kluger BM. Prevalence and cumulative incidence of caregiver reported aggression in advanced Parkinson’s disease and related disorders. Neurology: Clinical Practice. 2021. doi:10.1212/CPJ.0000000000001110

Ayele R, Macchi ZA, Dini M, Bock M, Katz M, Pantilat S, Jones J, Kluger BM. The experience of community neurologists providing care for patients with neurodegenerative illness during the COVID-19 pandemic. Neurology. 2021. doi:10.1212/WNL.0000000000012363

Macchi ZA, Ayele R, Dini M, Lamira J, Katz M, Pantilat S, Jones J, Kluger BM. Lessons from the COVID-19 pandemic for improving outpatient neuropalliative care: A qualitative study of patient and caregiver perspectives. Palliative Medicine. 2021. doi:10.1177/02692163211017383

Macchi ZA, Kletenik I, Olvera C, Holden SK. Psychiatric co-morbidities in functional movement disorders: A retrospective cohort study. Movement Disorders: Clinical Practice. 2021. doi:10.1002/mdc3.13226.

Macchi ZA, Tarolli C, Kluger BM. Palliative care in movement disorders: An evolving field. Current Neurology & Neurosciences Report. 2021. doi:10.1007/s11910-021-01091-5.

Macchi ZA, DeMasters BK, Orjuela K, Pastula D, Piquet A, Baca C. Glioblastoma as an autoimmune limbic encephalitis mimic: A case and review of the literature. Journal of Neuroimmunology. 2020. doi:10.1016/j.jneuroim.2020.577214.

Macchi ZA,Koljack CE, Miyasaki J, Katz M, Galifianakis N, Prizer LP, Sillau SH, Kluger BM. Patient and caregiver characteristics associated with caregiver burden in Parkinson’s disease: A palliative care approach. Annals of Palliative Medicine. 2019. doi:10.21037/apm.2019.10.01.

Macchi Z, Wang Y, Moore D, Katz J, Saperstein D, Walk D, Simpson E, Genge A, Bertorini T, Fernandes J, Swenson A, Elman L, Dimachkie M, Herbelin L, Miller J, Lu J, Swerdlow RH, Barohn RJ. A multi-center screening trial of rasagiline in patients with amyotrophic lateral sclerosis: Possible mitochondrial biomarker target engagement. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 2015:1-8. doi:10.3109/21678421.2015.1026826.

A list of Dr. Macchi's publications can be found on Colorado PROFILES