Zachary Macchi, MD - Instructor

Headshot of Dr. Zachary Macchi

Contact Info



Residency, Neurology, University of Colorado (University Hospital) Program

MD, University of Kansas School of Medicine

Professional Titles

Palliative Care and Aging Research Fellow


Zachary Macchi, MD, is an Aging and Palliative Care Research Fellow  in the Department of Neurology at the University of Colorado. He obtained his undergraduate and medical degrees at the University of Kansas and completed his residency in Neurology at the University of Colorado (CU) Anschutz. An area of ongoing interest to Dr. Macchi is palliative care for neurologic illness, or neuropalliative care. Throughout fellowship he continues to work on a number of projects related to neuropalliative care for patients with neurodegenerative conditions, like Alzheimer’s disease and Parkinson’s disease. His current work focuses on aggression as a behavioral disturbance in Parkinson’s disease and other forms of parkinsonism, identifying factors which contribute to such behaviors and their consequences for patients and caregivers while also researching ways to detect and manage aggression in the outpatient setting.

Recent Publications

Macchi, Z. A., Carlisle, T. C., & Filley, C. M. (2022). Prognosis in substance abuse-related acute toxic leukoencephalopathy: A scoping review. Journal of the neurological sciences, 442, 120420. 

Bock, M., Katz, M., Sillau, S., Adjepong, K., Yaffe, K., Ayele, R., Macchi, Z. A., Pantilat, S., Miyasaki, J. M., & Kluger, B. (2022). What's in the Sauce? The Specific Benefits of Palliative Care for Parkinson's Disease. Journal of pain and symptom management, S0885-3924(22)00040-9. Advance online publication.

Macchi, Z. A., Miyasaki, J., Katz, M., Galifianakis, N., Sillau, S., & Kluger, B. M. (2021). Prevalence and Cumulative Incidence of Caregiver-Reported Aggression in Advanced Parkinson Disease and Related Disorders. Neurology. Clinical practice11(6), e826–e833.

Ayele, R., Macchi, Z. A., Dini, M., Bock, M., Katz, M., Pantilat, S. Z., Jones, J., & Kluger, B. M. (2021). Experience of Community Neurologists Providing Care for Patients With Neurodegenerative Illness During the COVID-19 Pandemic. Neurology97(10), e988–e995.

Macchi, Z. A., Ayele, R., Dini, M., Lamira, J., Katz, M., Pantilat, S. Z., Jones, J., & Kluger, B. M. (2021). Lessons from the COVID-19 pandemic for improving outpatient neuropalliative care: A qualitative study of patient and caregiver perspectives. Palliative medicine35(7), 1258–1266.

Macchi, Z. A., Kletenik, I., Olvera, C., & Holden, S. K. (2021). Psychiatric Comorbidities in Functional Movement Disorders: A Retrospective Cohort Study. Movement disorders clinical practice8(5), 725–732.

Macchi, Z. A., Tarolli, C. G., & Kluger, B. M. (2021). Palliative Care in Movement Disorders: an Evolving Field. Current neurology and neuroscience reports21(3), 5.

A list of Dr. Macchi's publications can be found on Colorado PROFILES