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DTSTART:20251102T020000
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DESCRIPTION:Investigating secretory protein carbonylation and crosslinking 
 as a mechanism for loss of insulin secretion in pre-type I diabetesIn the 
 early stages of type 1 diabetes (T1D)\, oxidative stress leads to irrevers
 ible protein modifications&mdash\;particularly by compounds like 4-hydroxy
 nonenal (4-HNE)&mdash\;which coincide with the decline and eventual loss o
 f insulin secretion by pancreatic &beta\;-cells. Many proteins critical to
  insulin vesicle transport and exocytosis contain conserved C2 domains wit
 h Lys-rich membrane-binding clusters that are highly reactive to 4-HNE. Wh
 ile 4-HNE is known to form crosslinks between amino acids\, its impact on 
 C2 domain function and insulin secretion remains poorly understood. In thi
 s talk\, Katie Schultz will present her research using crosslinking mass s
 pectrometry (XL-MS) to identify novel 4-HNE-induced crosslinks in C2 domai
 ns and discuss their implications for secretory pathway dysfunction in T1D
 .When: September 29\, 12 pm to 1 pmWhere: Main Conference Room\, BDC (M20)
 \, CU AnschutzSpeaker:Katie Schultz\, Master&rsquo\;s Student\, Research A
 ssistant\, Knight Lab\, Department of Chemistry\, CU Denver
DTEND:20250929T190000Z
DTSTAMP:20260722T141652Z
DTSTART:20250929T180000Z
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SUMMARY:Speaker: Katherine Schultz\, Dept. of Chemistry
UID:RFCALITEM639203266126624115
X-ALT-DESC;FMTTYPE=text/html:<strong>Investigating secretory protein carbon
 ylation and crosslinking as a mechanism for loss of insulin secretion in p
 re-type I diabetes</strong><br /><br />In the early stages of type 1 diabe
 tes (T1D)\, oxidative stress leads to irreversible protein modifications&m
 dash\;particularly by compounds like 4-hydroxynonenal (4-HNE)&mdash\;which
  coincide with the decline and eventual loss of insulin secretion by pancr
 eatic &beta\;-cells. Many proteins critical to insulin vesicle transport a
 nd exocytosis contain conserved C2 domains with Lys-rich membrane-binding 
 clusters that are highly reactive to 4-HNE. While 4-HNE is known to form c
 rosslinks between amino acids\, its impact on C2 domain function and insul
 in secretion remains poorly understood. In this talk\, Katie Schultz will 
 present her research using crosslinking mass spectrometry (XL-MS) to ident
 ify novel 4-HNE-induced crosslinks in C2 domains and discuss their implica
 tions for secretory pathway dysfunction in T1D.<br /><br /><strong>When: <
 /strong>September 29\, 12 pm to 1 pm<br /><strong>Where:</strong> Main Con
 ference Room\, BDC (M20)\, CU Anschutz<br /><br /><strong>Speaker:</strong
 ><br />Katie Schultz\, Master&rsquo\;s Student\, Research Assistant\, Knig
 ht Lab\, Department of Chemistry\, CU Denver<br />
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