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DESCRIPTION:Using Engineered Pseudoislets to Study the Role of Gap Junction
  Channels in Human Islet FunctionThis presentation will explore the modula
 tion of cell-cell electrical coupling among insulin-producing &beta\;-cell
 s and somatostatin-producing &delta\;-cell and investigate its impact on t
 he dynamics of both insulin and somatostatin release in the human islet.&n
 bsp\;Using an innovative human 'pseudo-islet' model\, our speaker will dis
 cuss:+ The extent of electrical coupling between &beta\;-cells\, ɑ-cells\,
  and &delta\;-cells in healthy human islets+ How modulating cell-cell elec
 trical coupling impacts insulin\, glucagon\, and somatostatin release dyna
 micsThe results of this work suggest an important role for gap junctions i
 n coordinating [Ca2+]i dynamics at high glucose in human islets and clearl
 y influence subsequent hormone secretion by b and a&nbsp\;cells. Further s
 tudies of human gap junctions among these various cell types would provide
  a deeper understanding of necessary structural elements that facilitate p
 roper hormone regulation and unction of the islet and potentially guide fu
 ture therapeutics for treating diabetes.&nbsp\;Please join us for this inn
 ovative exploration of islet biology research.When: Monday\, Jan 26\, 2026
 \, 12 pm to 1pm Where:&nbsp\;Main Conference Room\, Level 2\, BDC (M20)\, 
 CU AnschutzSpeaker:Claire H Levitt\,&nbsp\;Ph.D. Candidate\, Benninger Lab
 \, Department of Bioengineering\, CU Anschutz
DTEND:20260126T200000Z
DTSTAMP:20260511T145411Z
DTSTART:20260126T190000Z
LOCATION:
SEQUENCE:0
SUMMARY:Speaker: Claire Levitt\, Center for Bioengineering
UID:RFCALITEM639141080518902514
X-ALT-DESC;FMTTYPE=text/html:<p><strong>Using Engineered Pseudoislets to St
 udy the Role of Gap Junction Channels in Human Islet Function</strong><br 
 /></p><p>This presentation will explore the modulation of cell-cell electr
 ical coupling among insulin-producing &beta\;-cells and somatostatin-produ
 cing &delta\;-cell and investigate its impact on the dynamics of both insu
 lin and somatostatin release in the human islet.&nbsp\;</p><p>Using an inn
 ovative human 'pseudo-islet' model\, our speaker will discuss:<br />+ The 
 extent of electrical coupling between &beta\;-cells\, ɑ-cells\, and &delta
 \;-cells in healthy human islets<br />+ How modulating cell-cell electrica
 l coupling impacts insulin\, glucagon\, and somatostatin release dynamics<
 /p><p>The results of this work suggest an important role for gap junctions
  in coordinating [Ca2+]i dynamics at high glucose in human islets and clea
 rly influence subsequent hormone secretion by b and a&nbsp\;cells. Further
  studies of human gap junctions among these various cell types would provi
 de a deeper understanding of necessary structural elements that facilitate
  proper hormone regulation and unction of the islet and potentially guide 
 future therapeutics for treating diabetes.&nbsp\;Please join us for this i
 nnovative exploration of islet biology research.<br /></p><p><strong>When:
 </strong> Monday\, Jan 26\, 2026\, 12 pm to 1pm <br /><strong>Where:</stro
 ng>&nbsp\;Main Conference Room\, Level 2\, BDC (M20)\, CU Anschutz</p><p><
 strong>Speaker:</strong><br />Claire H Levitt\,&nbsp\;Ph.D. Candidate\, Be
 nninger Lab\, Department of Bioengineering\, CU Anschutz</p><p><strong></s
 trong></p>
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